Telemetry with Intravenous Infusion
When intravenous dosing is required in rodent telemetry studies, our preferred method is to use implanted vascular catheters and vascular access buttons (VABs). This more refined method allows remote dosing without any handling, restraint or needlesticks. The lack of stress-induced artefacts associated with traditional dosing methods enables acute effects of intravenously administered molecule to be easily detected. Use of VABs also facilitates the administration of longer duration drug infusions and improves welfare since animals may be group housed. Implanted animals may also be re-used thanks to great advances in catheter patency, reducing the overall number of animals used.