EEG Telemetry
For a more detailed assessment of the effects of your drug molecule on the central nervous system (CNS), the electroencephalogram (EEG) is recorded by telemetry. The use of fully implantable telemetry devices enables simultaneous recording of the EEG in conscious, freely moving group-housed animals.
Studies provide an opportunity for an early identification of CNS risk or may be used as a follow-up to investigate seizure liabilities observed in previously studies.
Fast fourier transform is used to quantify the EEG power across a range of frequency bands (delta, theta, alpha, beta and gamma). EEG is also supplemented with locomotor activity and body temperature data measured from the telemetry implant.
The model has been pharmacologically validated in our laboratory including assessments of statistical power and minimal detectable differences..
Studies standardly incorporate the sampling of blood using capillary microsampling for drug blood/plasma concentration assessment to allow safety margin calculations and PD/PD modelling of the data.
