{"id":2090,"date":"2022-07-05T15:20:57","date_gmt":"2022-07-05T14:20:57","guid":{"rendered":"https:\/\/vivonics-preclinical.com\/?p=2090"},"modified":"2023-02-23T12:47:18","modified_gmt":"2023-02-23T12:47:18","slug":"waveform-analysis-of-blood-pressure-telemetry-data","status":"publish","type":"post","link":"https:\/\/vivonics-preclinical.com\/2022\/07\/05\/waveform-analysis-of-blood-pressure-telemetry-data\/","title":{"rendered":"Waveform analysis of blood pressure telemetry data"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-post\" data-elementor-id=\"2090\" class=\"elementor elementor-2090\" data-elementor-post-type=\"post\">\n\t\t\t\t\t\t<section class=\"has_ae_slider elementor-section elementor-top-section elementor-element elementor-element-4b1e1d31 elementor-section-boxed elementor-section-height-default elementor-section-height-default ae-bg-gallery-type-default\" data-id=\"4b1e1d31\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"has_ae_slider elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-51e4d25 ae-bg-gallery-type-default\" data-id=\"51e4d25\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-12eb3ade elementor-widget elementor-widget-text-editor\" data-id=\"12eb3ade\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<style>\/*! elementor - v3.21.0 - 25-04-2024 *\/\n.elementor-widget-text-editor.elementor-drop-cap-view-stacked .elementor-drop-cap{background-color:#69727d;color:#fff}.elementor-widget-text-editor.elementor-drop-cap-view-framed .elementor-drop-cap{color:#69727d;border:3px solid;background-color:transparent}.elementor-widget-text-editor:not(.elementor-drop-cap-view-default) .elementor-drop-cap{margin-top:8px}.elementor-widget-text-editor:not(.elementor-drop-cap-view-default) .elementor-drop-cap-letter{width:1em;height:1em}.elementor-widget-text-editor .elementor-drop-cap{float:left;text-align:center;line-height:1;font-size:50px}.elementor-widget-text-editor .elementor-drop-cap-letter{display:inline-block}<\/style>\t\t\t\t<span style=\"font-weight: 400;\">Recordings of arterial blood pressure from conscious, freely-moving animals can be made via telemetry devices and are used routinely during the <\/span><a href=\"https:\/\/vivonics-preclinical.com\/\"><span style=\"font-weight: 400;\">drug discovery and development process <\/span><\/a><span style=\"font-weight: 400;\">to assess the<\/span> <span style=\"font-weight: 400;\">cardiovascular safety<\/span> <span style=\"font-weight: 400;\">of new drug molecules before they are tested in human trials.\u00a0\u00a0<\/span>\r\n\r\n<span style=\"font-weight: 400;\">Fully implantable telemetry devices sample the blood pressure waveform 500 to 1000 times every second (500-1000Hz) to produce high-fidelity recordings of the physiological signal.\u00a0 Despite the many data points that are contained within the blood pressure signal, conventional analysis tends to be quite simplistic involving the measurement of the maximum and minimum points on the pressure wave, equating to the systolic and diastolic arterial blood pressure.\u00a0\u00a0<\/span>\r\n\r\n<span style=\"font-weight: 400;\">These measures are useful and indicate if a drug is causing hyper- or hypotension.\u00a0 But, in only focusing on the maximum and minimum values, a lot of potentially useful data contained in the wave may be discarded.\u00a0 Changes in the shape of the blood pressure waveform are thought to occur because of changes in the state of the underlying network of blood vessels and\/or changes in the contraction of the heart.\u00a0 Quantifying these morphological changes is, however, challenging.\u00a0\u00a0<\/span>\r\n\r\n<span style=\"font-weight: 400;\">Vivonics is pleased to be a partner organization in the<\/span><a href=\"https:\/\/www.uantwerpen.be\/en\/projects\/inspire-safety-pharmacology\/\"><span style=\"font-weight: 400;\"> INSPIRE European Training Network in Safety Pharmacology.<\/span><\/a><span style=\"font-weight: 400;\">\u00a0 We are hosting the secondment of an early-stage researcher (ESR) who is investigating whether a more in-depth characterisation of blood pressure waveform data could enhance <\/span><a href=\"https:\/\/vivonics-preclinical.com\/cardiovascular-telemetry\/\"><span style=\"font-weight: 400;\">cardiovascular safety screening <\/span><\/a><span style=\"font-weight: 400;\">and give more mechanistic insight into the underlying physiological effects of test drugs.\u00a0\u00a0<\/span>\r\n\r\n<span style=\"font-weight: 400;\">A mathematical method known as <\/span><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/32347611\/\"><span style=\"font-weight: 400;\">Symmetric Projection Attractor Reconstruction (SPAR)<\/span><\/a><span style=\"font-weight: 400;\">, developed by Nandi and Aston (2020), will be used to make a detailed analysis of arterial blood pressure waveforms.\u00a0 This method utilises all the numerical data available, replotting and revisualizing them in a manner that allows unique quantification of changes in waveform morphology and variability.\u00a0 It is hoped that this additional analysis, from blood pressure data that is already available, will give a more detailed picture of the effects of new drug molecules on the state of the heart and peripheral vasculature.\u00a0 We wish our researcher all the very best in their investigations!<\/span>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"has_ae_slider elementor-section elementor-top-section elementor-element elementor-element-7923670 elementor-section-boxed elementor-section-height-default elementor-section-height-default ae-bg-gallery-type-default\" data-id=\"7923670\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"has_ae_slider elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-3713c08 ae-bg-gallery-type-default\" data-id=\"3713c08\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-6d588d8 elementor-author-box--avatar-yes elementor-author-box--biography-yes elementor-widget elementor-widget-author-box\" data-id=\"6d588d8\" data-element_type=\"widget\" data-widget_type=\"author-box.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<link rel=\"stylesheet\" href=\"https:\/\/vivonics-preclinical.com\/wp-content\/plugins\/elementor-pro\/assets\/css\/widget-theme-elements.min.css\">\t\t<div class=\"elementor-author-box\">\n\t\t\t\t\t\t\t<div  class=\"elementor-author-box__avatar\">\n\t\t\t\t\t<img decoding=\"async\" src=\"https:\/\/secure.gravatar.com\/avatar\/01f20fdf0e109b40f64c8a16186dc4f6?s=300&#038;d=mm&#038;r=g\" alt=\"Picture of Vivonics\" loading=\"lazy\">\n\t\t\t\t<\/div>\n\t\t\t\n\t\t\t<div class=\"elementor-author-box__text\">\n\t\t\t\t\n\t\t\t\t\t\t\t\t\t<div class=\"elementor-author-box__bio\">\n\t\t\t\t\t\tMatt is a highly trained scientist with many years of experience working in drug discovery and safety pharmacology groups in large pharmaceutical companies and CROs.\t\t\t\t\t<\/div>\n\t\t\t\t\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"<p>Recordings of arterial blood pressure from conscious, freely-moving animals can be made via telemetry devices and are used routinely during the drug discovery and development process to assess the cardiovascular safety of new drug molecules before they are tested in human trials. Fully implantable telemetry devices sample the blood pressure waveform 500 to 1000 times [&hellip;]<\/p>\n","protected":false},"author":5,"featured_media":2092,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"site-sidebar-layout":"default","site-content-layout":"default","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"default","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center 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