{"id":764,"date":"2022-02-11T12:04:07","date_gmt":"2022-02-11T12:04:07","guid":{"rendered":"https:\/\/vivonics-preclinical.com\/?page_id=764"},"modified":"2022-04-28T14:06:26","modified_gmt":"2022-04-28T14:06:26","slug":"in-vivo-qt-screen","status":"publish","type":"page","link":"https:\/\/vivonics-preclinical.com\/in-vivo-qt-screen\/","title":{"rendered":"In Vivo QT Screen"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-page\" data-elementor-id=\"764\" class=\"elementor elementor-764\" data-elementor-post-type=\"page\">\n\t\t\t\t\t\t<section class=\"has_ae_slider elementor-section elementor-top-section elementor-element elementor-element-20558492 elementor-section-boxed elementor-section-height-default elementor-section-height-default ae-bg-gallery-type-default\" data-id=\"20558492\" data-element_type=\"section\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t\t\t\t<div class=\"elementor-background-overlay\"><\/div>\n\t\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-no\">\n\t\t\t\t\t<div class=\"has_ae_slider elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-23c3078b ae-bg-gallery-type-default elementor-invisible\" data-id=\"23c3078b\" data-element_type=\"column\" data-settings=\"{&quot;animation&quot;:&quot;fadeInLeft&quot;,&quot;animation_tablet&quot;:&quot;none&quot;}\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-2b745d98 elementor-widget elementor-widget-heading\" data-id=\"2b745d98\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<style>\/*! elementor - v3.20.0 - 26-03-2024 *\/\n.elementor-heading-title{padding:0;margin:0;line-height:1}.elementor-widget-heading .elementor-heading-title[class*=elementor-size-]>a{color:inherit;font-size:inherit;line-height:inherit}.elementor-widget-heading .elementor-heading-title.elementor-size-small{font-size:15px}.elementor-widget-heading .elementor-heading-title.elementor-size-medium{font-size:19px}.elementor-widget-heading .elementor-heading-title.elementor-size-large{font-size:29px}.elementor-widget-heading .elementor-heading-title.elementor-size-xl{font-size:39px}.elementor-widget-heading .elementor-heading-title.elementor-size-xxl{font-size:59px}<\/style><h1 class=\"elementor-heading-title elementor-size-default\">In Vivo QT Screen<\/h1>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"has_ae_slider elementor-section elementor-top-section elementor-element elementor-element-fb6d6b0 elementor-section-boxed elementor-section-height-default elementor-section-height-default ae-bg-gallery-type-default\" data-id=\"fb6d6b0\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"has_ae_slider elementor-column elementor-col-50 elementor-top-column elementor-element elementor-element-de1121f elementor-hidden-tablet ae-bg-gallery-type-default elementor-invisible\" data-id=\"de1121f\" data-element_type=\"column\" data-settings=\"{&quot;animation&quot;:&quot;fadeInLeft&quot;,&quot;animation_tablet&quot;:&quot;none&quot;}\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-795f759 elementor-widget elementor-widget-image\" data-id=\"795f759\" data-element_type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<style>\/*! elementor - v3.20.0 - 26-03-2024 *\/\n.elementor-widget-image{text-align:center}.elementor-widget-image a{display:inline-block}.elementor-widget-image a img[src$=\".svg\"]{width:48px}.elementor-widget-image img{vertical-align:middle;display:inline-block}<\/style>\t\t\t\t\t\t\t\t\t\t<img fetchpriority=\"high\" decoding=\"async\" width=\"821\" height=\"570\" src=\"https:\/\/vivonics-preclinical.com\/wp-content\/uploads\/2022\/03\/invivoqtscreen-img01.png\" class=\"attachment-large size-large wp-image-1185\" alt=\"in vivo qt screen image 1\" srcset=\"https:\/\/vivonics-preclinical.com\/wp-content\/uploads\/2022\/03\/invivoqtscreen-img01.png 821w, https:\/\/vivonics-preclinical.com\/wp-content\/uploads\/2022\/03\/invivoqtscreen-img01-300x208.png 300w, https:\/\/vivonics-preclinical.com\/wp-content\/uploads\/2022\/03\/invivoqtscreen-img01-768x533.png 768w\" sizes=\"(max-width: 821px) 100vw, 821px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"has_ae_slider elementor-column elementor-col-50 elementor-top-column elementor-element elementor-element-7f6cf88 ae-bg-gallery-type-default elementor-invisible\" data-id=\"7f6cf88\" data-element_type=\"column\" data-settings=\"{&quot;animation&quot;:&quot;fadeInRight&quot;,&quot;animation_tablet&quot;:&quot;none&quot;}\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-5b633f1 elementor-hidden-desktop elementor-hidden-mobile elementor-widget elementor-widget-image\" data-id=\"5b633f1\" data-element_type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t<img fetchpriority=\"high\" decoding=\"async\" width=\"821\" height=\"570\" src=\"https:\/\/vivonics-preclinical.com\/wp-content\/uploads\/2022\/03\/invivoqtscreen-img01.png\" class=\"attachment-large size-large wp-image-1185\" alt=\"in vivo qt screen image 1\" srcset=\"https:\/\/vivonics-preclinical.com\/wp-content\/uploads\/2022\/03\/invivoqtscreen-img01.png 821w, https:\/\/vivonics-preclinical.com\/wp-content\/uploads\/2022\/03\/invivoqtscreen-img01-300x208.png 300w, https:\/\/vivonics-preclinical.com\/wp-content\/uploads\/2022\/03\/invivoqtscreen-img01-768x533.png 768w\" sizes=\"(max-width: 821px) 100vw, 821px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-62d14fe elementor-widget elementor-widget-text-editor\" data-id=\"62d14fe\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<style>\/*! elementor - v3.20.0 - 26-03-2024 *\/\n.elementor-widget-text-editor.elementor-drop-cap-view-stacked .elementor-drop-cap{background-color:#69727d;color:#fff}.elementor-widget-text-editor.elementor-drop-cap-view-framed .elementor-drop-cap{color:#69727d;border:3px solid;background-color:transparent}.elementor-widget-text-editor:not(.elementor-drop-cap-view-default) .elementor-drop-cap{margin-top:8px}.elementor-widget-text-editor:not(.elementor-drop-cap-view-default) .elementor-drop-cap-letter{width:1em;height:1em}.elementor-widget-text-editor .elementor-drop-cap{float:left;text-align:center;line-height:1;font-size:50px}.elementor-widget-text-editor .elementor-drop-cap-letter{display:inline-block}<\/style>\t\t\t\t<p><span style=\"font-weight: 400;\">In vitro cardiac ion channel screening and stem cell derived cardiomyocyte assays provide a valuable initial assessment of potential cardiac liabilities of a new drug. However, for an early in vivo assessment of effects on cardiac electrophysiology, the anaesthetised guinea pig has been proven to be an effective and translatable assay, highly predictive for QTc effects in large animal telemetry studies and the clinic*.\u00a0 ECGs are recorded, alongside blood pressure and heart rate, and are measured to assess the effects on standard parameters, including QTc interval, PR interval and QRS duration.\u00a0 Left ventricular pressure and the electromechanical window may also be assessed for more detailed investigations.<\/span><\/p>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"has_ae_slider elementor-section elementor-top-section elementor-element elementor-element-d9511e6 elementor-section-boxed elementor-section-height-default elementor-section-height-default ae-bg-gallery-type-default\" data-id=\"d9511e6\" data-element_type=\"section\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;,&quot;shape_divider_top&quot;:&quot;tilt&quot;}\">\n\t\t\t\t\t<div class=\"elementor-shape elementor-shape-top\" data-negative=\"false\">\n\t\t\t<svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" viewBox=\"0 0 1000 100\" preserveAspectRatio=\"none\">\n\t<path class=\"elementor-shape-fill\" d=\"M0,6V0h1000v100L0,6z\"\/>\n<\/svg>\t\t<\/div>\n\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"has_ae_slider elementor-column elementor-col-50 elementor-top-column elementor-element elementor-element-1f53da5 ae-bg-gallery-type-default elementor-invisible\" data-id=\"1f53da5\" data-element_type=\"column\" data-settings=\"{&quot;animation&quot;:&quot;fadeInLeft&quot;,&quot;animation_tablet&quot;:&quot;none&quot;}\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-03f0ede elementor-hidden-desktop elementor-widget elementor-widget-image\" data-id=\"03f0ede\" data-element_type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t<img decoding=\"async\" width=\"524\" height=\"523\" src=\"https:\/\/vivonics-preclinical.com\/wp-content\/uploads\/2022\/03\/invivoqtscreen-img03.png\" class=\"attachment-large size-large wp-image-1181\" alt=\"in vivo qt screen image 03\" srcset=\"https:\/\/vivonics-preclinical.com\/wp-content\/uploads\/2022\/03\/invivoqtscreen-img03.png 524w, https:\/\/vivonics-preclinical.com\/wp-content\/uploads\/2022\/03\/invivoqtscreen-img03-300x300.png 300w, https:\/\/vivonics-preclinical.com\/wp-content\/uploads\/2022\/03\/invivoqtscreen-img03-150x150.png 150w\" sizes=\"(max-width: 524px) 100vw, 524px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-5972b2d elementor-widget elementor-widget-text-editor\" data-id=\"5972b2d\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<p><span style=\"font-weight: 400;\">Multiple doses of test drug are assessed in each experiment, and microsamples of blood are taken for drug concentration analysis enabling PK\/PD relationships to be derived.\u00a0<\/span><\/p><p><span style=\"font-weight: 400;\">The small compound requirement of the assay makes it ideal for use during lead optimisation when de-risking projects prior to more expensive regulatory studies.<\/span><\/p><p><span style=\"font-weight: 400;\">The assay has been validated in our laboratory, and the statistical power and minimal detectable differences using various group sizes have been published for the key parameters measured.\u00a0 A group size of n=4 will allow detection of 8% changes in QTc interval, 10% changes in QRS duration and 11% changes in PR interval.**\u00a0<\/span><span style=\"background-color: var( --e-global-color-2c3e913c );\">Increasing to n=6 allows detection of 7% changes in QTc interval, 8% changes in QRS duration and 9% changes in PR interval.<\/span><\/p><p><span style=\"font-weight: 400;\">The single in vivo screen provides a significant amount of information that we interpret for your project team.\u00a0 We will also integrate the data with other relevant project information, including in vitro \/ in silico ion channel data and predicted human concentrations.<\/span><\/p>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-eb1b14e elementor-widget elementor-widget-text-editor\" data-id=\"eb1b14e\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<p><span style=\"font-weight: 400;\">*Ref:\u00a0 Morissette et al.,\u00a0 The anesthetised guinea pig: an effective early cardiovascular derisking and lead optimisation model. J Pharmacol Toxicol Methods. 2013 Jul-Aug;68(1):137-49.<\/span><\/p><p><span style=\"font-weight: 400;\">**Ref: Skinner et al., Differentiating multichannel block on the guinea pig ECG: Use of Tpeak-Tend and J-Tpeak. J Pharmacol Toxicol Methods Sep-Oct 2021;111:<\/span><\/p>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"has_ae_slider elementor-column elementor-col-50 elementor-top-column elementor-element elementor-element-04b78d2 elementor-hidden-tablet elementor-hidden-mobile ae-bg-gallery-type-default elementor-invisible\" data-id=\"04b78d2\" data-element_type=\"column\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;,&quot;animation&quot;:&quot;fadeInRight&quot;,&quot;animation_tablet&quot;:&quot;none&quot;,&quot;animation_mobile&quot;:&quot;none&quot;}\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-72780b7 elementor-widget elementor-widget-image\" data-id=\"72780b7\" data-element_type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t<img decoding=\"async\" width=\"265\" height=\"265\" src=\"https:\/\/vivonics-preclinical.com\/wp-content\/uploads\/2021\/12\/dots-orange.png\" class=\"attachment-large size-large wp-image-475\" alt=\"dots orange\" srcset=\"https:\/\/vivonics-preclinical.com\/wp-content\/uploads\/2021\/12\/dots-orange.png 265w, https:\/\/vivonics-preclinical.com\/wp-content\/uploads\/2021\/12\/dots-orange-150x150.png 150w\" sizes=\"(max-width: 265px) 100vw, 265px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-e0a9b46 elementor-invisible elementor-widget elementor-widget-image\" data-id=\"e0a9b46\" data-element_type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeInRight&quot;,&quot;_animation_tablet&quot;:&quot;none&quot;,&quot;_animation_delay&quot;:400}\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t<img decoding=\"async\" width=\"524\" height=\"523\" src=\"https:\/\/vivonics-preclinical.com\/wp-content\/uploads\/2022\/03\/invivoqtscreen-img03.png\" class=\"attachment-large size-large wp-image-1181\" alt=\"in vivo qt screen image 03\" srcset=\"https:\/\/vivonics-preclinical.com\/wp-content\/uploads\/2022\/03\/invivoqtscreen-img03.png 524w, https:\/\/vivonics-preclinical.com\/wp-content\/uploads\/2022\/03\/invivoqtscreen-img03-300x300.png 300w, https:\/\/vivonics-preclinical.com\/wp-content\/uploads\/2022\/03\/invivoqtscreen-img03-150x150.png 150w\" sizes=\"(max-width: 524px) 100vw, 524px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"<p>In Vivo QT Screen In vitro cardiac ion channel screening and stem cell derived cardiomyocyte assays provide a valuable initial assessment of potential cardiac liabilities of a new drug. However, for an early in vivo assessment of effects on cardiac electrophysiology, the anaesthetised guinea pig has been proven to be an effective and translatable assay, [&hellip;]<\/p>\n","protected":false},"author":3,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"site-sidebar-layout":"no-sidebar","site-content-layout":"page-builder","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"disabled","ast-breadcrumbs-content":"","ast-featured-img":"disabled","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center 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